Busulfan is a bifunctional alkylating agent known chemically as 1,4butanediol, dimethanesulfonate. Busulfan was the mainstay of the chemotherapeutic treatment of chronic myeloid leukemia cml until it was displaced by the new gold standard, imatinib, though it is still in use to a degree as a result of the drugs relative low cost. Busulfan testing web order form seattle cancer care alliance. Busulfan investigated as a drug, mutagen, reproductive effector, and tumorigen. It is also used for the treatment of myeloproliferative disorders, including polycythemia vera and myeloid metaplasia. See actual entry in rtecs for complete information. Busulfan is not recommended for use during pregnancy. Busulfan is a methanesulfonate ester that is butane1,4diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. Highlights of prescribing information these highlights do not include all the information needed to use. Busulfan pharmacokinetics and toxicity were monitored in young rhesus macaques at two dosing levels 4 and 6 mgkg. As a result, buinduced myelotoxicity has been complemented by adding. Give us at least 48 hours notice prior to sample arrival.
Variation assessment report as adopted by the chmp with all. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia although it has been largely replaced by newer drugs. If previously receiving 60 mg daily dose, resume treatment at 40 mg daily. If busulfan injection or diluted busulfan injection solution contacts the skin or mucosa, wash the skin or mucosa thoroughly with water. Despite prophylactic therapy with phenytoin, one seizure 142 patients was reported during an autologous transplantation clinical trial of busulfex. Busulfan side effects, dosage, interactions drugs everyday health search. Feb 19, 2019 busulfan is a cancer medicine that interferes with the growth and spread of cancer cells in the body. In a word, we confirm that the usage of the concentration of res needs to be strictly determined. Do not put the busulfex into an intravenous bag or largevolume syringe that does not contain normal. Busulfan comes as a solution liquid to be given intravenously into a vein over 2 hours by a doctor or nurse in a medical facility. Busulfan is used in conditioning regimens prior to hct.
Busulfan oral myleran side effects, medical uses, and. Apr 03, 20 at each analysis time and condition, a difference in busulfan content between the two assays was observed such that the busulfan content after adding dma was greater than 90 or 95 % of the initial concentration. Pdf association between busulfan exposure and outcome in. Please fill out this form electronically, print it out and fax to busulfan lab at 206 6067397 or click submit by email button and send this form via your email account.
Highlights of prescribing information these highlights do. Here are the steps to inserting a pdf file into a word document. This page brings back any words that contain the word or letter you enter from a large scrabble dictionary. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to. Busulfan was approved by the us food and drug administration fda for treatment of chronic myeloid leukemia cml in 1999.
A list of words that contain busulfan, and words with busulfan in them. To arrive at the top five similar articles we use a wordweighted algorithm to compare words from the title and abstract of. The package insert recommends a minimum of three, and preferably four or more. Tdm of intravenous busulfan was performed in 34 pediatric hsct patients with. Under object type, select adobe acrobat document and. Pdf busulfan, combined with therapeutic drug monitoringguided dosing. Word will convert the pdf to editable text and you can then copy and paste that text into your office document. These examples have been automatically selected and may contain sensitive content. Busulfan is dissolved in a mixed solvent of n,ndimethyl acetamide with a volume ratio of 33% and polyethylene glycol 400 with a volume ratio of 67%, wherein the concentration of the busulfan is 6mgml, and the mixed solvent contains organic acid and alkali metal or alkaline earth metal salt of organic acid, which account for 0. Avoid runoff into storm sewers, ditches, and waterways. Busulfan comes as a tablet to take by mouth once a day.
Get emergency medical help if you have signs of an allergic reaction hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling. Highdose thiotepa, busulfan, cyclophosphamide and asct without. The object dialog box will appear select create from file. Population pharmacokinetic modelling of busulfan and the influence. Busulfex busulfan side effects, images, uses, dosage. This emedtv resource lists other precautions and warnings with busulfan, including a list of possible complications that may occur with the drug. Mar 01, 2019 busulfan concentrate injection description. We also have lists of words that end with busulfan, and words that start with busulfan. Share them with others and work together at the same time. Busulfan injection is intended for intravenous administration. Nov 14, 2019 metronidazole injection, usp is a sterile, nonpyrogenic, isotonic, buffered parenteral dosage form of metronidazole in water for injection. Intravenous bu has been substituted for the oral drug because of an improved. Bestdose accurately calculates busulfan intravenous dosage requirements to achieve. Busulfan definition, a potent cytotoxic substance, c6h14o6s2, used in the treatment of chronic myeloid leukemia.
Each 100 ml contains metronidazole 500 mg 5 mgml and sodium chloride 790 mg in water for injection. All transfer procedures require strict adherence to aseptic techniques, preferably employing a vertical laminar flow safety hood while wearing gloves and protective clothing. The proportionality assumption for cox regression was tested by adding a. Busulfan dosage people who receive busulfan will be given a dosage based on their weight, response to the medicine, other medications they are taking, and a number of other factors. In some cases, health care professionals may use the trade name bulsufex or other names myleran when referring to the generic drug name busulfan. Furthermore, this combination of agents has been well studied in high dosage. Microsoft word allows you to create a variety of documents for practically every aspect of your business. In the text group click the dropdown arrow for object and select object. How to insert audio or video clips into microsoft word 2010. Only select registry of toxic effects of chemical substances rtecs data is presented here. Collaborate for free with an online version of microsoft word. It should not be used unless a diagnosis of chronic myelogenous leukemia has been adequately established and the responsible physician is knowledgeable in assessing response to chemotherapy.
Effect of weight and maturation on busulfan clearance in. Place your cursor by clicking on the area where you wish to insert the pdf document. Busulfan definition of busulfan by medical dictionary. Find patient medical information for busulfan intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Microsoft word 2010 includes native functionality that allows you to import, or insert, a pdf file into a word document. The file location will now appear on the object dialog box. Busulfex busulfan injection is intended for intravenous administration. Nov 16, 2017 what are the possible side effects of busulfan busulfan, busulfex, myleran.
Busulfan is an alkylating agent originally given qid by mouth, generally with cyclophosphamide in the socalled bucy regimens. Is adobe still open when youre trying to insert into word. If youre looking to insert the contents of your pdf file into an office file, as opposed to simply inserting the pdf as an attachment, then your best bet is to open that pdf with word 20 or 2016. Busulfan injection may cause seizures during therapy with the medication. Therapeutic drug monitoring is essential for intravenous busulfan.
Cancer research uk helped develop the drugs busulfan and melphalan to treat neuroblastoma and helped fund an international trial showing they could improve survival for children with advanced neuroblastoma. Medlineplus information on busulfan myleran and busulfan bulsulfex lay language summaries of important information about these drugs. Cn102151257a busulfan injection and preparation method. Busulfan can induce apoptosis of bone marrow hematopoietic cells of mice via.
Busulfan, allogeneic stem cell transplantation, therapeutic drug. The easiest ways to insert a pdf into word, either as an image or in an editable format, online or offline. Definition from the nci drug dictionary detailed scientific definition and other names for this drug. Contain spills with an inert absorbent material such as soil, sand or oil dry. Inserting audio or video clips into microsoft word 2010. This prescription chemotherapy drug comes as a tablet that is taken once a day, until blood cell counts return to normal. Adding melphalan to optimal busulfan exposure is associated with a high.
Prior to taking busulfan, let your doctor know if you have a seizure disorder, lung disease, or allergies. Busulfan is also being studied in the treatment of other types of cancer. Open the word document and select insert on the ribbon. Busulfan concentrate injection fda prescribing information. It is usually given every 6 hours for 4 days for a total of 16 doses before bone marrow transplant. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have. Busulfex fda prescribing information, side effects and uses. These doses were then employed to condition two animals at each dose level prior to autologous transplantation of genetically modified cells using our standard methods. It should be administered under the supervision of a qualified physician who is experienced in allogeneic hematopoietic stem cell transplantation, the use of cancer chemotherapeutic drugs and the management of patients with severe pancytopenia. The variation proposed amendments to the smpc, annex ii, labelling and package leaflet. Cyclophosphamide, long known to have dose limiting cardiac toxicity and risk of. Oral chemotherapy protocols busulfan gwent healthcare nhs trust 27082008 version 1.
All these data indicated that res in high dosage in vivo can significantly. Seizures have been reported in patients receiving highdose oral busulfan at doses producing plasma drug levels similar to those achieved following the recommended dosage of busulfex. Busulfan definition is an antineoplastic agent c6h14o6s2 used in the treatment of chronic myelogenous leukemia. Find patient medical information for busulfan oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Embed pdf in word embed a pdf document into microsoft word. The dose should be increased only if the response is inadequate after three weeks.
If you become pregnant or think you may be pregnant, tell your doctor immediately. Words that contain busulfan words containing busulfan. Highlights of prescribing information palmarplantar. It is unknown if this drug passes into breast milk. Run and import pdf files into the program by clicking add pdf. Busulfan definition of busulfan by the free dictionary.
Follow applicable special handling and disposal procedures. Request pdf therapeutic drug monitoring is essential for intravenous busulfan. It is supplied as a clear, colorless, sterile, solution in 10 ml singledose vials. Nov 16, 2017 busulfan is dissolved in n,ndimethylacetamide dma, 3. With word 2007 in the xp operating system it was easy, i just clicked and draged pdf the document into the word document. Resveratrol changes spermatogonial stem cells sscs activity and.
Busulfan article about busulfan by the free dictionary. Physicochemical stability of busulfan in injectable. Therefore, personalized bu dosing via therapeutic drug monitoring tdm needs to be. Busulfan, cyclophosphamide, and melphalan or busulfan and. Prescribing information myleran busulfan 2mg scored tablets warning myleran is a potent drug. Discuss the use of reliable forms of birth control with your doctor. Pdf, or portable document format, files are commonly used for product specification sheets and user manuals. Busulfex busulfan injection is a potent cytotoxic drug that causes profound myelosuppression at the recommended dosage.
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